AbstractIn investigating the effect of gravitational changes on development, it is instructive to think of altered gravity (Δg) as a teratogen - that is, an environmental factor influencing development. Observed effects on skeletal development include: suppression of morphogenesis in centrifuged mouse limb buds; advanced fusion stages in centrifuged mouse palates; smaller crown rump lengths (CRL) and decreased number of pregnancies in centrifuged rats and mice; altered differentiation of growth plates in young growing rats in space; and decreased length of calcified long bone regions in fetal rats exposed to microgravity (μg) in utero. These studies show that Δg is able to alter development in vivo and in vitro and suggest that Δg operates, at least in part, at the cellular level.


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    Title :

    Teratogenic effects of gravitational changes


    Contributors:
    Duke, P.J. (author) / Montufar-Solis, D. (author) / Daane, E. (author)

    Published in:

    Advances in Space Research ; 14 , 8 ; 281-287


    Publication date :

    1994-01-01


    Size :

    7 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



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