Mice deprived of water for 24 h showed an increase in hematocrit and loss of body weight comparable to that seen in men during space flight. The increase in hematocrit was entirely due to a decrease in plasma volume and was associated with suppression of erythropoiesis, but with no significant change in the serum titer of a presumptive humoral regulator of erythropoiesis, Erythroid Stimulating Activity (ESA). Mice deprived of water for 24 h may be a useful model for the study of the early hematological effects of space flight. The suppression of erythropoiesis due to a relative erythrocytosis appears to be independent of ESA.


    Access

    Access via TIB

    Check availability in my library


    Export, share and cite



    Title :

    Effect of dehydration on erythropoiesis in mice - Relevance to the 'anemia' of space flight


    Contributors:

    Publication date :

    1978-08-01


    Type of media :

    Miscellaneous


    Type of material :

    No indication


    Language :

    English






    Studies on erythropoiesis. II.

    Borsook, H. / Ratner, K. / Tattrie, B. | NTRS | 1969



    Enhancing Flight Department Relevance

    Cannon, J. / Garvey, W. | British Library Online Contents | 2009