Abstract Samples of plasmid DNA were irradiated with pulsed 18.9 nm radiation originating from a Mo X-ray laser pumped in GRIP configuration at the LASERIX facility [1]. Surface doses of up to 500 kGray were delivered with a repetition rate of 10 Hz and average pulse energy of 200 nJ. The occurrence of single and double strand breaks not present in controls having undergone the same treatment except for the XRL irradiation can be seen as a clear effect of the XRL irradiation. This confirms the role of direct effects in DNA damages as previously seen with low energy ions [2, 3] and electrons.


    Access

    Check access

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Strand Breaks in DNA Samples Induced with LASERIX


    Contributors:
    Zielbauer, B. (author) / Habib, J. (author) / Kazamias, S. (author) / Guilbaud, O. (author) / Pittman, M. (author) / Ros, D. (author) / Hervé du Penhoat, M. -A. (author) / Touati, A. (author) / Sech, C. Le (author) / Porcel, E. (author)

    Published in:

    X-Ray Lasers 2008 ; 7 ; 409-411


    Publication date :

    2009-01-01


    Size :

    3 pages





    Type of media :

    Article/Chapter (Book)


    Type of material :

    Electronic Resource


    Language :

    English




    Strand Breaks in DNA Samples Induced with LASERIX

    Zielbauer, B. / Habib, J. / Kazamias, S. et al. | British Library Conference Proceedings | 2009


    Toward an x-ray laser beamline facility: LASERIX (Invited Paper) [5196-16]

    Jamelot, G. / Ros, D. / Pittman, M. et al. | British Library Conference Proceedings | 2004


    Heavy ion induced double strand breaks in bacteria and bacteriophages

    Micke, U. / Schäfer, M. / Anton, A. et al. | Elsevier | 1991


    Theoretical consideration of the chemical pathways for radiation-induced strand breaks

    Chatterjee, A. / Koehl, P. / Magee, J.L. | Elsevier | 1987


    Heavy ion induced DNA double strand breaks in cells of E. coli

    Schäfer, M. / Schmitz, C. / Bücker, H. | Elsevier | 1994