Abstract Protective effects of indomethacin, a prototype prostaglandin-inhibiting agent, against early and late sequelae of radiation injury (after X-rays or γ-rays) in mice were investigated. The following tissues or organs were examined: hematopoietic tissue, esophagus, jejunum, colon, lung, hair follicles, and tissues involved in the development of radiation-induced leg contractures. In addition, the effect of indomethacin was tested against radiation-induced carcinogenesis. In all experiments, the radiation was delivered as a single dose. Indomethacin led to significant protection of hematopoietic tissue, by a factor of 1.3. There was also some protection against radiation-induced pneumonitis and against radiation-induced carcinogenesis (protection factor of 1.2). The other tissues tested showed no change in their radioresponse after being treated with indomethacin. Thus, indomethacin can act as a radioprotective agent against both early and late sequelae of radiation, but its effect is dependent on the tissue tested. This protection is smaller than that observed with WR-2721. However, indomethacin combined with WR-2721 produced a radioprotective effect greater than the radioprotection achieved by individual treatments.


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    Titel :

    Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin


    Beteiligte:
    Milas, L. (Autor:in) / Nishiguchi, I. (Autor:in) / Hunter, N. (Autor:in) / Murray, D. (Autor:in) / Fleck, R. (Autor:in) / Ito, H. (Autor:in) / Travis, E. (Autor:in)

    Erschienen in:

    Advances in Space Research ; 12 , 2-3 ; 265-271


    Erscheinungsdatum :

    01.01.1991


    Format / Umfang :

    7 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch




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