The primary objective of this research project is to test the hypothesis that corticosteroids contribute to the adverse skeletal effects of space flight. To achieve this objective, serum corticosteroids, which are known to increase during space flight, must be maintained at normal physiologic levels in flight rats by a combination of adrenalectomy and corticosteroid supplementation via implanted hormone pellets. Bone analyses in these animals will then be compared to those of intact flight rats that, based on past experience, will undergo corticosteroid excess and bone loss during space flight. The results will reveal whether maintaining serum corticosteroids at physiologic levels in flight rats affects the skeletal abnormalities that normally develop during space flight. A positive response to this question would indicate that the bone loss and decreased bone formation associated with space flight are mediated, at least in part, by corticosteroid excess.


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    Titel :

    Role of Corticosteroids in Bone Loss During Space Flight


    Beteiligte:

    Erscheinungsdatum :

    01.01.1998


    Medientyp :

    Report


    Format :

    Keine Angabe


    Sprache :

    Englisch


    Schlagwörter :


    Role of Corticosteroids in Bone Loss During Space Flight

    United States; National Aeronautics and Space Administration | British Library Conference Proceedings | 1998



    Countermeasures against space flight related bone loss

    Leblanc, Adrian / Schneider, Victor | NTRS | 1992


    Inhibition of bone formation during space flight

    Morey, E. R. / Baylink, D. J. | NTRS | 1978


    Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss

    LeBlanc, A. / Matsumoto, T. / Jones, J. et al. | NTRS | 2011